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KMID : 1007320150210020079
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Journal of the Korean Society of Menopause
2015 Volume.21 No. 2 p.79 ~ p.81
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G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women’s Health
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Kim Mi-Jin
Kim Tae-Hee
Lee Hae-Hyeog
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Abstract
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Estrogen - the female sexual hormone playing the most important role - plays a physiologically significant role, not only regulating in cell signals with second messenger but also being active in regulating transcription. Estrogen receptor (ER) which is a protein accepting estrogen not only play the role of a transcription factor combining with other genes to regulate their activity like other nuclear receptors but also performs external activities, combining with DNA, etc. G-protein coupled ER (GPER) that has been recently discovered exists as 7-membrane and has non-genomic (rapid) signaling. These functions, however, are not extensively addressed. This paper discusses the roles of GPER and its physiological mechanism.
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KEYWORD
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Estradiol, Estrogens, Genomics, GTP-binding proteins
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